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Discover & Evaluate · Solution 02
R&D Intelligence

R&D intelligence that turns the world's evidence into direction.

Synthesize peer-reviewed science, every global clinical trial, and the full patent literature into one evidence layer, then find the white space where the science is open and the need is high.

Where is the unmet need highest and the science least crowded in IBD?
Literature38k
IL-23 antagonism review
TL1A/DR3 mechanism
TYK2 selectivity data
Trials5.1k
Ph II, gut-selective
Ph III, oral advanced
China Ph I cluster
Patents9.7k
JAK family, crowded
TL1A, sparse
Integrin, emerging
Synthesized direction
Oral, gut-selective TL1A sits in open IP white space with high unmet need in moderate-to-severe IBD, strongest opportunity in the set.
Need 0.92 IP density 0.22 41 trials cited
Structured conference search

Every major meeting, parsed into structured, searchable evidence.

ASCO, AACR, ESMO, ASH, DDW and more, One Zyme reads each abstract, poster, and presentation and turns it into structured data you can filter by drug, target, indication, phase, conference, or date.

Conference Presentations

Conference Presentations

Pharma and biotech conference presentations, structured for search.

All Conferences
All Categories
All Phases
From MM/DD/YYYYTo MM/DD/YYYY
Expand Your Search ?
TitleSummaryConferenceStudy CategoryPhasePublished Date
Gut-selective TL1A antagonist in moderate-to-severe ulcerative colitisEndoscopic remission sustained through week 52 with a favorable safety profile versus placebo.DDWInterventional TrialPhase II2026-05-31
TYK2 allosteric inhibitor for pediatric plaque psoriasisLong-term durability and safety data across a 96-week open-label extension.AADInterventional TrialPhase III2026-03-09
Oral IL-23 receptor antagonist in Crohn's diseaseDose-ranging results suggest endoscopic response comparable to injectable benchmarks.ECCOInterventional TrialPhase II2026-02-18
Real-world durability of JAK1-selective therapy in rheumatoid arthritisRegistry analysis across 2,400 patients comparing persistence and discontinuation.ACRReal-World Evidence, 2026-01-22
ROR-γt inverse agonist in moderate-to-severe hidradenitis suppurativaFirst-in-class oral candidate shows early signal on inflammatory lesion count.EADVInterventional TrialPhase I2025-10-14
Peer-reviewed research

Synthesize the world's peer-reviewed science and use AI to connect the dots.

One Zyme reads full-text literature, resolves it to the right targets, mechanisms, and assets, and distills consensus, conflict, and emerging hypotheses, with every claim traceable to its source.

Synthesizing full-text · cited · entity-resolved papers reasoned over · 38,402
Incoming literaturepeer-reviewed
Distilled findingsconsensus · conflict · emerging
Mechanism consensusstrong · 41 trials · 12k patients
Across 41 controlled trials, oral IL-23 antagonism shows a consistent endoscopic-remission benefit over placebo in moderate-to-severe IBD.Lancet
Conflicting findingmixed · 9 cohorts
The JAK-class cardiovascular safety signal is inconsistent between real-world and RCT cohorts, One Zyme flags it for risk-stratified interpretation.ARD
Emerging hypothesisemerging · 6 papers
TL1A/DR3 modulation may decouple efficacy from broad immunosuppression, early, but convergent across independent groups.Nature
0Papers indexed
0Journals & sources
Full-textNot just abstracts
100%Claims cited
Global clinical trials

Read every trial in the world as structured evidence.

One Zyme normalizes registries worldwide, including China, into one structured landscape, so you can see where programs are concentrating, what's reading out, and where activity is thin.

Live landscape ClinicalTrials.gov · EUCTR · ChiCTR · JPRN · ANZCTR · +9 trials structured · 640k+

Clinical Trials

Every registry worldwide, normalized into one structured, searchable landscape.

Trial registry
All registries
Trial phase
All phases
Sponsor name
All sponsors
Trial IDTitleRegistryPhaseIndication
ChiCTR2600126800Risk factors for poor wound healing after artificial-liver catheter removalChiCTRN/ALiver failure
ChiCTR2600126801Transcutaneous electrical acupoint stimulation in acute pancreatitisChiCTRN/AAcute pancreatitis
ChiCTR2600126790INSURE vs LISA surfactant delivery in extremely preterm infantsChiCTRN/ANeonatal RDS
NCT06914207Oral TYK2 inhibitor in moderate-to-severe ulcerative colitisClinicalTrials.govPhase IIUlcerative colitis
2026-501883-42IL-23 antagonist maintenance therapy in Crohn's diseaseEUCTRPhase IIICrohn's disease
Structured by One ZymeLive
IndicationLiver failure
InterventionArtificial-liver support
DesignObservational cohort
SponsorZhejiang Univ. Hospital
PhaseN/A
RegistryChiCTR
0Trials structured
14Registries unified
ChinaFully integrated
DailyRefresh cadence
Patent intelligence

Don't settle for patent search. Get best-in-class analysis on top.

One Zyme clusters the global patent corpus by mechanism and approach, revealing where IP is dense, where it's thinning, and where the genuine white space is forming. While One Zyme doesn't provide legal advice, it can give you an exceptionally deep analytical breakdown of patents and patent families.

Patent density by approach USPTO · EPO · CNIPA · WIPO
JAK-family inhibitors
small molecule · oral
Density0
Heavily patented
IL-23 pathway
antibody & oral
Density0
Crowded
ROR-γt inverse agonists
small molecule
Density0
TYK2 allosteric
small molecule · selective
Density0
Gut-selective integrin
oral · localized
Density0
Emerging white space
TL1A / DR3 axis
antibody & oral
Density0
Open white space
White space × unmet need

Find the white space where innovation is missing, and need is high.

One Zyme plots every approach by competitive density and unmet need at once. The opportunity isn't just the empty space, it's the empty space where patients still have no good option.

Opportunity map · IBDdensity × unmet need
Unmet need →
Opportunity zone · high need · open
Oral gut-selective TL1A
TYK2 · pediatric IBD
Competitive / IP density →
Open white spaceCrowded
High-fit opportunity Crowded Other approaches
Opportunity shortlistranked by fit
1
Oral gut-selective TL1A
need 0.92 · IP density 0.22
0.94
2
TYK2 · pediatric IBD
need 0.81 · IP density 0.34
0.86
3
ROR-γt · oral · HS
need 0.74 · IP density 0.45
0.78
4
IL-23 × IL-17 bispecific
need 0.68 · IP density 0.58
0.71
How the assessment works

White space only matters when it meets unmet need.

01

Map the white space

Cluster the literature, trials, and patent corpus by mechanism to expose where the science is open and competition is thin.

02

Quantify unmet need

Score each indication on burden of disease, remission rates, treatment-failure populations, and durability gaps, grounded in cited evidence.

03

Size the market & dynamics

Pressure-test each opportunity against addressable population, pricing and reimbursement precedent, competitive intensity, and the shifting standard of care.

04

Find the overlap

Rank approaches by the intersection of open white space, high unmet need, and attractive market dynamics, the opportunities worth a program, not just a paper.

A new workflow model

No more legacy databases.

With Cortellis & PubMed
With One Zyme
Read abstracts one at a time and hope you caught the key papers
Synthesize full-text literature into cited consensus, conflict, and hypotheses
Pull trial lists from registries and reconcile them by hand
One structured global trial landscape, including China, refreshed daily
Run patent searches separately, with no innovation view
A clustered patent map that shows density, thinning, and white space
Assess unmet need in a different tool, on different data
Unmet-need scoring tied to the same evidence layer
Eyeball white space from disconnected exports
A ranked opportunity map of white space × unmet need
Point-in-time, and stale the day you finish
Continuously updated as new science, trials, and IP appear

Powered by the One Zyme intelligence layer.

Every R&D workflow runs on the same agents, data, and evidence trail that power the rest of the platform.

Explore Models & Data →
Global biopharma data layer
Scientific document intelligence
China intelligence layer
Biopharma knowledge graph
Agentic research engine
Evidence & citation layer
Patent & IP layer

Point your R&D strategy at the white space that matters.

Get a strategic briefing tailored to your therapeutic areas, target mechanisms, and pipeline priorities.