/* ============================================================
   One Zyme · R&D Intelligence, page-specific dynamic styles.
   Layered on _solutions.css + se-page.css.
   Engines:
     hero  (.rdh-*) , evidence synthesis command center
     lit   (.lit-*) , peer-reviewed literature synthesis
     trl   (.trl-*) , global clinical-trial landscape
     pat   (.pat-*) , patent innovation map
     ws    (.ws-*)  , white space × unmet need matrix (marquee)
   Reduced-motion aware (see rd-page.js).
   ============================================================ */

/* ════════ HERO · evidence synthesis ════════ */
.rdh-stage{background:rgba(244,240,230,0.025);border:1px solid var(--oz-on-dark-line);border-radius:18px;padding:18px;display:flex;flex-direction:column;gap:14px;box-shadow:0 30px 70px rgba(0,0,0,0.35);}
.rdh-q{display:flex;align-items:center;gap:12px;background:var(--oz-midnight);border:1px solid var(--oz-on-dark-line-2);border-radius:12px;padding:13px 15px;}
.rdh-q .ico{width:26px;height:26px;border-radius:9999px;background:var(--oz-cyan-soft);display:flex;align-items:center;justify-content:center;flex-shrink:0;}
.rdh-q .tx{font-size:13.5px;line-height:1.4;color:var(--oz-on-dark-1);}
.rdh-lanes{display:grid;grid-template-columns:repeat(3,1fr);gap:10px;}
.rdh-lane{background:var(--oz-midnight);border:1px solid var(--oz-on-dark-line);border-radius:12px;padding:13px;display:flex;flex-direction:column;gap:9px;}
.rdh-lane .lh{display:flex;align-items:center;justify-content:space-between;font-family:var(--oz-font-mono);font-size:9px;letter-spacing:0.08em;text-transform:uppercase;color:var(--oz-on-dark-3);font-weight:600;}
.rdh-lane .lh .n{color:var(--oz-cyan);font-size:13px;font-weight:600;letter-spacing:0;font-variant-numeric:tabular-nums;}
.rdh-item{font-family:var(--oz-font-mono);font-size:9.5px;color:var(--oz-on-dark-2);background:rgba(244,240,230,0.03);border:1px solid var(--oz-on-dark-line);border-radius:6px;padding:6px 8px;display:flex;align-items:center;gap:6px;}
.rdh-item::before{content:"";width:5px;height:5px;border-radius:9999px;background:var(--oz-cyan);opacity:0.8;flex-shrink:0;}
.rdh-synth{background:linear-gradient(180deg, rgba(6,182,212,0.08), rgba(10,22,40,0.6));border:1px solid var(--oz-cyan-ring);border-radius:12px;padding:15px;display:flex;flex-direction:column;gap:8px;}
.rdh-synth .h{font-family:var(--oz-font-mono);font-size:9.5px;letter-spacing:0.10em;text-transform:uppercase;color:var(--oz-cyan);font-weight:600;}
.rdh-synth .body{font-family:var(--oz-font-display);font-size:15px;line-height:1.4;color:var(--oz-bone);}
.rdh-synth .body em{font-style:italic;color:var(--oz-cyan);}
.rdh-synth .pills{display:flex;flex-wrap:wrap;gap:5px;margin-top:2px;}

/* ════════ shared dark marquee shell ════════ */
.rd-dark{
  background:
    radial-gradient(900px 480px at 18% 0%,  rgba(6,182,212,0.10),  transparent 60%),
    radial-gradient(800px 440px at 92% 100%, rgba(42,74,107,0.40), transparent 62%),
    linear-gradient(180deg, #0A1628 0%, #0F1B30 100%);
  color:var(--oz-bone);
}
.rd-dark .section-head h2{color:var(--oz-bone);}
.rd-dark .section-head h2 em{color:var(--oz-cyan);font-style:italic;}
.rd-dark .section-head p{color:var(--oz-on-dark-2);}
.rd-dark .section-head .pill{color:var(--oz-cyan);border:1px solid var(--oz-cyan-ring);background:transparent;}
.rd-dark .section-head .pill .dot{background:var(--oz-cyan);}

.rd-stage{
  position:relative;background:rgba(10,22,40,0.55);
  -webkit-backdrop-filter:blur(12px);backdrop-filter:blur(12px);
  border:1px solid var(--oz-on-dark-line-2);border-radius:24px;overflow:hidden;
  box-shadow:0 30px 70px rgba(0,0,0,0.4);
}
.rd-bar{display:flex;align-items:center;gap:14px;padding:16px 22px;border-bottom:1px solid var(--oz-on-dark-line);background:rgba(244,240,230,0.02);font-family:var(--oz-font-mono);font-size:11px;letter-spacing:0.10em;text-transform:uppercase;color:var(--oz-on-dark-3);font-weight:600;}
.rd-bar .live{display:inline-flex;align-items:center;gap:8px;color:var(--oz-cyan);}
.rd-bar .live .d{width:8px;height:8px;border-radius:9999px;background:var(--oz-cyan);box-shadow:0 0 0 3px var(--oz-cyan-soft);animation:rd-pulse 2s ease-in-out infinite;}
@keyframes rd-pulse{0%,100%{box-shadow:0 0 0 3px var(--oz-cyan-soft);}50%{box-shadow:0 0 0 7px rgba(6,182,212,0.04);}}
.rd-bar .scan{margin-left:auto;color:var(--oz-on-dark-2);}
.rd-bar .scan b{color:var(--oz-bone);font-weight:600;}
.rd-h{display:flex;align-items:center;justify-content:space-between;font-family:var(--oz-font-mono);font-size:10px;letter-spacing:0.12em;text-transform:uppercase;color:var(--oz-on-dark-3);font-weight:600;}
.rd-h .tag{color:var(--oz-cyan);}

.rd-stats{display:grid;grid-template-columns:repeat(4,1fr);border-top:1px solid var(--oz-on-dark-line);background:rgba(10,22,40,0.4);}
.rd-stat{padding:18px 22px;border-right:1px solid var(--oz-on-dark-line);}
.rd-stat:last-child{border-right:0;}
.rd-stat .v{font-family:var(--oz-font-mono);font-size:23px;font-weight:500;color:var(--oz-bone);letter-spacing:-0.02em;line-height:1;font-variant-numeric:tabular-nums;display:block;}
.rd-stat .l{display:block;font-family:var(--oz-font-mono);font-size:10px;color:var(--oz-on-dark-3);letter-spacing:0.08em;text-transform:uppercase;margin-top:6px;font-weight:600;}
@media (max-width:720px){.rd-stats{grid-template-columns:repeat(2,1fr);}.rd-stat:nth-child(2){border-right:0;}.rd-stat:nth-child(1),.rd-stat:nth-child(2){border-bottom:1px solid var(--oz-on-dark-line);}}

/* ════════ 1 · LITERATURE SYNTHESIS ════════ */
.lit-grid{display:grid;grid-template-columns:0.95fr 1.05fr;gap:0;}
@media (max-width:1000px){.lit-grid{grid-template-columns:1fr;}}
.lit-feed-wrap{padding:22px;border-right:1px solid var(--oz-on-dark-line);}
@media (max-width:1000px){.lit-feed-wrap{border-right:0;border-bottom:1px solid var(--oz-on-dark-line);}}
.lit-feed{display:flex;flex-direction:column;gap:8px;margin-top:14px;}
.lit-paper{display:grid;grid-template-columns:1fr auto;gap:10px;align-items:center;padding:11px 13px;border-radius:10px;background:rgba(244,240,230,0.02);border:1px solid var(--oz-on-dark-line);}
.lit-paper.enter{animation:rd-enter .55s var(--oz-ease) both;}
@keyframes rd-enter{from{opacity:0;transform:translateY(-12px) scale(0.98);}to{opacity:1;transform:none;}}
.lit-paper .ti{font-size:12px;color:var(--oz-bone);font-weight:600;letter-spacing:-0.005em;line-height:1.3;}
.lit-paper .mt{font-family:var(--oz-font-mono);font-size:9px;color:var(--oz-on-dark-3);margin-top:3px;letter-spacing:0.02em;}
.lit-paper .jr{font-family:var(--oz-font-mono);font-size:8.5px;letter-spacing:0.06em;text-transform:uppercase;font-weight:700;color:var(--oz-cyan);background:var(--oz-cyan-soft);padding:4px 8px;border-radius:6px;white-space:nowrap;}
.lit-find-wrap{padding:22px;display:flex;flex-direction:column;gap:12px;}
.lit-find{background:rgba(244,240,230,0.025);border:1px solid var(--oz-on-dark-line);border-radius:12px;padding:15px;opacity:0;transform:translateY(8px);transition:opacity .5s var(--oz-ease), transform .5s var(--oz-ease);}
.lit-find.show{opacity:1;transform:none;}
.lit-find .fh{display:flex;align-items:center;justify-content:space-between;gap:10px;margin-bottom:9px;}
.lit-find .fh .k{font-family:var(--oz-font-mono);font-size:9.5px;letter-spacing:0.10em;text-transform:uppercase;color:var(--oz-cyan);font-weight:600;}
.lit-find .fh .ev{font-family:var(--oz-font-mono);font-size:9px;color:var(--oz-on-dark-3);letter-spacing:0.04em;}
.lit-find .body{font-size:13px;color:var(--oz-on-dark-1);line-height:1.45;}
.lit-find .body b{color:var(--oz-bone);font-weight:600;}
.lit-find .meter{height:6px;border-radius:9999px;background:var(--oz-on-dark-line);overflow:hidden;margin-top:11px;}
.lit-find .meter > i{display:block;height:100%;width:0;border-radius:9999px;background:var(--oz-cyan);transition:width 1.1s var(--oz-ease);}
.lit-find.warn .fh .k{color:#E8A33D;}
.lit-find.warn .meter > i{background:#E8A33D;}
.lit-find .cite{font-family:var(--oz-font-mono);font-size:9px;color:var(--oz-cyan);background:var(--oz-cyan-soft);padding:1px 6px;border-radius:9999px;letter-spacing:0.03em;margin-left:5px;white-space:nowrap;}

/* ════════ 2 · CLINICAL-TRIAL LANDSCAPE ════════ */
.trl-grid{display:grid;grid-template-columns:1.4fr 0.9fr;gap:0;}
@media (max-width:1000px){.trl-grid{grid-template-columns:1fr;}}
.trl-matrix-wrap{padding:22px;border-right:1px solid var(--oz-on-dark-line);}
@media (max-width:1000px){.trl-matrix-wrap{border-right:0;border-bottom:1px solid var(--oz-on-dark-line);}}
.trl-matrix{margin-top:16px;display:grid;grid-template-columns:84px repeat(5,1fr);gap:6px;}
.trl-matrix .ch{font-family:var(--oz-font-mono);font-size:9px;letter-spacing:0.08em;text-transform:uppercase;color:var(--oz-on-dark-3);font-weight:600;display:flex;align-items:center;justify-content:center;padding:4px 0;}
.trl-matrix .rh{font-family:var(--oz-font-mono);font-size:10px;letter-spacing:0.06em;text-transform:uppercase;color:var(--oz-on-dark-2);font-weight:600;display:flex;align-items:center;}
.trl-cell{position:relative;border:1px solid var(--oz-on-dark-line);border-radius:8px;min-height:46px;display:flex;align-items:center;justify-content:center;font-family:var(--oz-font-mono);font-size:14px;font-weight:600;color:var(--oz-on-dark-2);background:rgba(244,240,230,0.02);font-variant-numeric:tabular-nums;transition:background .5s var(--oz-ease), border-color .5s var(--oz-ease), color .5s var(--oz-ease);}
.trl-cell.h1{background:rgba(6,182,212,0.06);color:var(--oz-on-dark-1);}
.trl-cell.h2{background:rgba(6,182,212,0.12);border-color:var(--oz-cyan-ring);color:var(--oz-bone);}
.trl-cell.h3{background:rgba(6,182,212,0.22);border-color:var(--oz-cyan-ring);color:var(--oz-bone);box-shadow:0 0 0 1px var(--oz-cyan-ring);}
.trl-side{padding:22px;display:flex;flex-direction:column;gap:10px;}
.trl-sig{display:grid;grid-template-columns:auto 1fr;gap:10px;align-items:start;background:rgba(244,240,230,0.025);border:1px solid var(--oz-on-dark-line);border-radius:10px;padding:12px 13px;}
.trl-sig .ic{width:7px;height:7px;border-radius:9999px;background:var(--oz-cyan);margin-top:5px;box-shadow:0 0 0 3px var(--oz-cyan-soft);}
.trl-sig .tx{font-size:12px;color:var(--oz-on-dark-1);line-height:1.4;}
.trl-sig .tx b{color:var(--oz-bone);font-weight:600;}
.trl-sig .tx .mt{font-family:var(--oz-font-mono);font-size:9px;color:var(--oz-on-dark-3);margin-top:3px;letter-spacing:0.02em;}

/* ════════ 3 · PATENT INNOVATION MAP ════════ */
.pat-stage{background:linear-gradient(180deg,#0F1E36 0%, var(--oz-midnight) 100%);border:1px solid var(--oz-on-dark-line);border-radius:24px;overflow:hidden;color:var(--oz-on-dark-1);}
.pat-head{display:flex;align-items:center;justify-content:space-between;padding:20px 24px;border-bottom:1px solid var(--oz-on-dark-line);}
.pat-grid{padding:24px;display:grid;grid-template-columns:repeat(3,1fr);gap:12px;}
@media (max-width:900px){.pat-grid{grid-template-columns:1fr;}}
.pat-cluster{background:rgba(244,240,230,0.025);border:1px solid var(--oz-on-dark-line);border-radius:14px;padding:18px;display:flex;flex-direction:column;gap:10px;transition:border-color .4s var(--oz-ease), background .4s var(--oz-ease);}
.pat-cluster .nm{font-family:var(--oz-font-display);font-size:16px;font-weight:500;color:var(--oz-bone);letter-spacing:-0.01em;}
.pat-cluster .sub{font-family:var(--oz-font-mono);font-size:9.5px;color:var(--oz-on-dark-3);letter-spacing:0.04em;margin-top:-4px;}
.pat-bar{height:8px;border-radius:9999px;background:var(--oz-on-dark-line);overflow:hidden;}
.pat-bar > i{display:block;height:100%;width:0;border-radius:9999px;background:var(--oz-cyan);transition:width 1.1s var(--oz-ease);}
.pat-meta{display:flex;align-items:center;justify-content:space-between;font-family:var(--oz-font-mono);font-size:10px;color:var(--oz-on-dark-2);}
.pat-meta .dens{letter-spacing:0.06em;text-transform:uppercase;font-weight:600;font-size:9px;color:var(--oz-on-dark-3);}
.pat-cluster.crowded .pat-bar > i{background:#E96B59;}
.pat-cluster.crowded{border-color:rgba(233,107,89,0.3);}
.pat-cluster.crowded .dens{color:#F2A293;}
.pat-cluster.open{border-color:var(--oz-cyan-ring);background:rgba(6,182,212,0.06);box-shadow:0 0 0 1px var(--oz-cyan-ring);}
.pat-cluster.open .pat-bar > i{background:#3FD27F;}
.pat-cluster.open .dens{color:#3FD27F;}
.pat-flag{margin-top:auto;font-family:var(--oz-font-mono);font-size:9px;letter-spacing:0.08em;text-transform:uppercase;font-weight:700;color:var(--oz-on-dark-3);opacity:0;transition:opacity .4s var(--oz-ease);}
.pat-cluster.open .pat-flag{color:#3FD27F;opacity:1;}
.pat-cluster.crowded .pat-flag{color:#F2A293;opacity:1;}

/* ════════ 4 · WHITE SPACE × UNMET NEED (marquee) ════════ */
.ws{background:var(--oz-bone);}
.ws-stage{display:grid;grid-template-columns:1.5fr 0.9fr;gap:0;background:linear-gradient(180deg,#0F1E36 0%, var(--oz-midnight) 100%);border:1px solid var(--oz-on-dark-line);border-radius:24px;overflow:hidden;color:var(--oz-on-dark-1);}
@media (max-width:1000px){.ws-stage{grid-template-columns:1fr;}}
.ws-plot-wrap{padding:26px 26px 22px;border-right:1px solid var(--oz-on-dark-line);}
@media (max-width:1000px){.ws-plot-wrap{border-right:0;border-bottom:1px solid var(--oz-on-dark-line);}}
.ws-plot{position:relative;height:420px;margin:30px 0 8px 44px;border-left:1px solid var(--oz-on-dark-line-2);border-bottom:1px solid var(--oz-on-dark-line-2);}
.ws-plot::before{content:"";position:absolute;inset:0;background-image:linear-gradient(var(--oz-on-dark-line) 1px, transparent 1px),linear-gradient(90deg, var(--oz-on-dark-line) 1px, transparent 1px);background-size:25% 25%;opacity:0.5;pointer-events:none;}
/* opportunity zone, high need (top), low density (left) */
.ws-zone{position:absolute;left:0;top:0;width:42%;height:46%;border:1px dashed var(--oz-cyan-ring);border-radius:12px;background:linear-gradient(135deg, rgba(6,182,212,0.12), rgba(6,182,212,0.02));opacity:0;transition:opacity .7s var(--oz-ease);}
.ws-zone.show{opacity:1;}
.ws-zone .zl{position:absolute;left:12px;top:10px;font-family:var(--oz-font-mono);font-size:9.5px;letter-spacing:0.10em;text-transform:uppercase;color:var(--oz-cyan);font-weight:700;}
.ws-dot{position:absolute;transform:translate(-50%,-50%);width:13px;height:13px;border-radius:9999px;background:var(--oz-on-dark-line-2);border:1px solid rgba(244,240,230,0.3);opacity:0;transition:opacity .45s var(--oz-ease), transform .45s var(--oz-ease);}
.ws-dot.show{opacity:0.8;}
.ws-dot.crowded{background:rgba(233,107,89,0.5);border-color:rgba(233,107,89,0.6);}
.ws-dot.opp{width:17px;height:17px;background:radial-gradient(circle, #FFE08A, #E8A33D);border:1px solid #FFE9B0;box-shadow:0 0 0 4px rgba(255,209,102,0.18), 0 0 18px rgba(255,179,71,0.5);opacity:0;}
.ws-dot.opp.show{opacity:1;animation:ws-opp-pulse 2.2s ease-in-out infinite;}
@keyframes ws-opp-pulse{0%,100%{box-shadow:0 0 0 3px rgba(255,209,102,0.16), 0 0 12px rgba(255,179,71,0.45);}50%{box-shadow:0 0 0 7px rgba(255,209,102,0.30), 0 0 26px rgba(255,190,90,0.95), 0 0 44px rgba(255,179,71,0.55);}}
@media (prefers-reduced-motion: reduce){.ws-dot.opp.show{animation:none;}}
.ws-dot .lbl{position:absolute;left:50%;bottom:140%;transform:translateX(-50%);font-family:var(--oz-font-sans);font-size:10.5px;font-weight:600;color:var(--oz-bone);white-space:nowrap;background:rgba(10,22,40,0.85);border:1px solid var(--oz-cyan-ring);border-radius:6px;padding:3px 7px;opacity:0;transition:opacity .4s var(--oz-ease);pointer-events:none;}
.ws-dot.opp.show .lbl{opacity:1;}
/* axis labels */
.ws-axis-y{position:absolute;left:-34px;top:50%;transform:translateY(-50%) rotate(-90deg);transform-origin:center;font-family:var(--oz-font-mono);font-size:9px;letter-spacing:0.10em;text-transform:uppercase;color:var(--oz-on-dark-3);font-weight:600;white-space:nowrap;}
.ws-axis-x{text-align:center;font-family:var(--oz-font-mono);font-size:9px;letter-spacing:0.10em;text-transform:uppercase;color:var(--oz-on-dark-3);font-weight:600;margin:10px 0 0 44px;}
.ws-axis-ends{display:flex;justify-content:space-between;font-family:var(--oz-font-mono);font-size:8.5px;letter-spacing:0.04em;color:var(--oz-on-dark-3);margin:4px 0 0 44px;}
/* shortlist */
.ws-side{padding:26px 24px;display:flex;flex-direction:column;gap:12px;}
.ws-short{display:grid;grid-template-columns:26px 1fr auto;gap:11px;align-items:center;background:rgba(244,240,230,0.025);border:1px solid var(--oz-on-dark-line);border-radius:10px;padding:12px 13px;opacity:0;transform:translateX(10px);transition:opacity .5s var(--oz-ease), transform .5s var(--oz-ease);}
.ws-short.show{opacity:1;transform:none;}
.ws-short.lead{border-color:var(--oz-cyan-ring);background:linear-gradient(180deg, rgba(6,182,212,0.10), rgba(10,22,40,0.4));}
.ws-short .rk{width:26px;height:26px;border-radius:7px;background:rgba(255,209,102,0.14);color:#FFD166;display:flex;align-items:center;justify-content:center;font-family:var(--oz-font-mono);font-size:11px;font-weight:600;}
.ws-short .nm{font-size:12.5px;color:var(--oz-bone);font-weight:600;letter-spacing:-0.005em;}
.ws-short .mt{font-family:var(--oz-font-mono);font-size:9px;color:var(--oz-on-dark-3);margin-top:3px;letter-spacing:0.02em;}
.ws-short .sc{font-family:var(--oz-font-mono);font-size:13px;color:#3FD27F;font-weight:600;font-variant-numeric:tabular-nums;}

/* unmet-need legend chips */
.ws-legend{display:flex;flex-wrap:wrap;gap:14px;margin-top:6px;}
.ws-legend span{font-family:var(--oz-font-mono);font-size:9px;letter-spacing:0.06em;text-transform:uppercase;color:var(--oz-on-dark-3);font-weight:600;display:inline-flex;align-items:center;gap:6px;}
.ws-legend span::before{content:"";width:9px;height:9px;border-radius:9999px;}
.ws-legend .lg-opp::before{background:#FFD166;}
.ws-legend .lg-crowd::before{background:rgba(233,107,89,0.6);}
.ws-legend .lg-other::before{background:var(--oz-on-dark-line-2);}

@media (prefers-reduced-motion: reduce){
  .rd-bar .live .d{animation:none;}
  .lit-paper.enter{animation:none;}
  .lit-find,.ws-dot,.ws-short,.ws-zone{opacity:1;transform:none;transition:none;}
}